Question: How Do High Levels Of Alkaline Phosphatase Indicate A Bone Abnormality?

What does high alkaline phosphatase indicate?

High ALP usually means that either the liver has been damaged or a condition causing increased bone cell activity is present.

If other liver tests such as bilirubin, aspartate aminotransferase (AST), or alanine aminotransferase (ALT) are also high, usually the increased ALP is caused by liver damage or disease..

What does alkaline phosphatase do in bone?

Bone ALP is a major regulator of bone mineralization. It hydrolyzes inorganic pyrophosphate which is a naturally occurring inhibitor of mineralization. Bone ALP also provides inorganic phosphate (from pyrophosphate and organic phosphomonoesters) for the synthesis of hydroxyapatite [7,8].

What medications cause elevated alkaline phosphatase?

The following drugs may affect the level of alkaline phosphatase in the blood:Allopurinol.Antibiotics.Anti-inflammatory medicines.Birth control pills.Certain diabetes medicines.Chlorpromazine.Cortisone.Male hormones.More items…•

Can high alkaline phosphatase cause itching?

Itching sometimes gets worse during pregnancy or if you’re undergoing hormone replacement therapy. Serum alkaline phosphatase (ALP). People with itch related to liver disease may have elevated ALP.

What bone disorders cause elevated alkaline phosphatase?

Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.

How do you lower alkaline phosphatase?

Make changes to your dietavoid fruits and vegetables served with high-calorie sauces or added sugar and salt.eat fish at least twice a week, ideally those high in omega-3 fatty acids, such as salmon or trout.opt for fat-free or low-fat milk and dairy products.More items…•

What do you do if your alkaline phosphatase is high?

High alkaline phosphatase levels may mean there is damage to your liver or that you have a type of bone disorder….High alkaline phosphatase levels in the liver can indicate:Cirrhosis.Hepatitis.A blockage in the bile duct.Mononucleosis, which can sometimes cause swelling in the liver.

Can high alkaline phosphatase be treated?

The treatment for abnormal ALP levels depends entirely on the cause of the condition. Slightly abnormal ALP levels are generally no cause for concern as ALP levels naturally fluctuate during the day and vary from person to person. People with malnutrition should adjust their diet accordingly or take supplements.

Is alkaline phosphatase a tumor marker?

Serum ALP was found to be a valuable tumor marker with high specificity in osteosarcoma.

Can low vitamin D cause high alkaline phosphatase?

Thus, vitamin D deficiency is usually accompanied by normal blood levels for calcium and phosphorus, high-normal or elevated levels of PTH, normal to elevated levels of total alkaline phosphatase, a low 24-hour urine calcium excretion rate, and low levels of total 25(OH)D.

What is alkaline phosphatase normal range?

The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (µkat/L). Normal values may vary slightly from laboratory to laboratory. They also can vary with age and gender. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women.

Can arthritis cause high alkaline phosphatase?

Increased concentration of serum alkaline phosphatase (ALP) is a common feature in rheumatoid arthritis (RA), although its origin remains unclear.